Histological Changes on liver and kidney in rat fed on different concentrations of Aflatoxin

Jalal  Shaker, Rana; Mohamed Thalij, Karkiz; Salman Bdooy, Amen

	Histological Changes on liver and kidney in rat fed on different concentrations of Aflatoxin
Tikrit Journal of Pure Science
Article 1, Volume 18, Issue 4, 2013, Pages 115-119
Authors
Rana Jalal Shaker; Karkiz Mohamed Thalij; Amen Salman Bdooy
Abstract
Aflatoxin poisons are the most dangerous toxins for human and animal health.The biological studies, showed that, giving afltoxin with the food of the experimental animals , There are different pathogenic effects take place . These effects include; some disorder with immune system , mutation, carcinogenic effects with different organs of the body especially the liver and kidney ,which considered the subjected organs for the toxins. Aflatoxin poisons were produced with gradient concentrations (0.312 ,0.625, 1.250 , 2.5 mg/kg of feed) .These concentrations mixed with food and feed to the animals for 21 days in different treatments. Then, the animals were killed, and histopathology of the tissue slices were made from liver and kidney . Physiological changes in the liver and kidney tissues were recorded .These changes ,represented a swollen of the liver cells with some bleeding ,and RBC aggregate in the liver tissue. However, the kidney tissues, hese changes are increased and become pathogenic especially with high levels of aflatoxin . Also, an extensive shrinkage noticed with the kidney`s glomeruli cells and the proximal convoluted tubules cells become degraded of epithelia. These cells were filled with degradation cells. Also , the filtrate of the glomeruli and Collecting tubes have allot of degraded of epithelia cells, and some of them become unconnected .

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