Efficacy of oral mefenamic acid in treatment of rash of Gianotti–Crosti syndrome: A prospective noncontrolled case-series study

Abdul-Jaleel, Usama

	Efficacy of oral mefenamic acid in treatment of rash of Gianotti–Crosti syndrome: A prospective noncontrolled case-series study
Al-Qadisiah Medical Journal
Article 1, Volume 9, Issue 2, 2013, Pages 261-268 PDF (0 K)
Author
Usama Abdul-Jaleel
Abstract
Background: Gianotti–Crosti syndrome (GCS) is a characteristic cutaneous response to viral & non-viral infection mainly affecting children .No treatment appears to shorten the course of the disease which lasts 3-8 weeks .Mefenamic acid is NSAID which acts as competitive inhibitor of prostaglandin biosynthesis. Objective: To assess the efficacy and safety of oral mefenamic acid 50 mg twice a day in the treatment of (GCS) for 10 days Methods : In this prospective non-controlled case series study, 36 patients were identified as having Gianotti–Crosti syndrome by dermatologist in Al-Diwanyia Teaching Hospital , from January 2012 to May 2013 and they have been treated with oral mefenamic acid 50 mg twice a day for 10 days. Results : 36 patients entered the current study. The mean age of the patients was 2 1.2 ( 1 - 5.5 ) years. There were 19 ( 52.8 %) females and 17( 47.2 %) males. Complete clearance of the rash of GCS at all sites was seen in 33 patients ( 91.6 %) within 10 days of initiation of the therapy, leaving the the skin with fine desquamation (P<0.05) .Two patients experienced no change in the rash until after 3 weeks it got resolution of the rash and one patient get his rash resolved after one month. None of the patients suffered adverse effects during the usage of treatment and the period of the follow-up. Conclusion : oral mefenamic acid seems to be effective in treatment of Gianotti–Crosti syndrome
Keywords
Gianotti; mefenamic acid

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