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Stability of Resistance Induced by Escherichia coli in Comparison with That Carried by Clinical Isolates in Vivo | ||
| Kerbala Journal of Medicine | ||
| Article 1, Volume 6, Issue 1, 2013, Pages 1546-1551 PDF (0 K) | ||
| Authors | ||
| Lubna A. Kafi; Sajaa R. kareem Al-Saedi; Ali A. Al-Khayyat | ||
| Abstract | ||
| ackground: The increasing incidence of resistance to a wide range of antibiotics by microorganisms is a major concern facing modern medicine because these antibiotics are widely used in human and veterinary medicine to treat and prevent diseases and as growth promoters in animal intensive industries. The consequences are severe. Infections caused by resistant microbes fail to respond to treatment, resulting in prolonged illness and greater risk of death. Objectives: The aims of this study are: 1-Comparing the changes of induced resistance in E.coli with that present in clinical isolates of the same microorganism. 2-Determine the properties of cefquinome especially the development of resistance and the stability of it Methods: fourteen strains of E.coli were collected from different disease cases: diarrhea (children= 6, calve= 3, poultry= 1), UTI (urine= 2), mastitis (milk= 2) from Al-Yarmook hospital and farms of veterinary college (Baghdad). The MIC was estimated eight selected strains (4 sensitive and 4 resistances) before and after passages these strains in vivo for carried out the comparison. Results: A significant drop in induced resistance for sensitive strains as compared with clinical isolates which are not significant elevate in resistance. Most E.coli strains showed highly susceptible to cefquinome but some of them were appeared resistance although this antibacterial was newly used in this country. Conclusion: loss of induced resistance when passing in vivo because the resistant microorganisms actually were unstable group when comparison with stable resistance in clinical isolates was not changed when exposed to the same condition. Keywords: E. coli, MIC, in vivo, antibacterial. | ||
| Keywords | ||
| coli; MIC; in vivo; antibacterial | ||
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