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Asensitive colorimetric method for the determination of Methyldopa in pharmaceutical preparation via oxidative coupling organic reaction with Thiamine Hydrochloride in the presence of potassium periodate | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 4, Issue 6, 2013, Pages 69-77 PDF (0 K) | ||
| Authors | ||
| Muneer . A . A . AL-Da; ; Rashwan . F. AL-Moswi | ||
| Abstract | ||
| A simple, accurate and sensitive spectrophotometric method for the determination of Methyldopa in pure and pharmaceutical preparations has been developed .The proposed method uses Thiamine Hydrochloride as anew chromogenic reagent . The method is based on the oxidative coupling reaction of Methyldopa with Thiamine Hydrochloride with potassium periodate in neutral media to form orange water soluble dye product , that has a maximum absorption at λmax 480 nm . Linear calibration graph was in the range of (1.00–25.00) µg.ml-1 with molar absorptivity of (0.53 ×104 L.mol-1.cm-1) ,a sandall sensitivity of (4.49 ×10-5 µg.cm-2) , correlation coefficient of (0.9997) , detection limit (0.38 µg.ml-1) and the relative standard deviation of RSD% (0.97) . The method was applied successfully for the determination of Methyldopa in pharmaceutical preparations and the value of recovery % was better than (102%) | ||
| Keywords | ||
| methyl; dopa drug; Spectrophotometric determination; Pharmacetical preparation | ||
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