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Myocardial infarction disease and its relationship with smoking and genes GSTM1 and GSTT1 in the province of Dhi Qar | ||
| Journal of Univesity of Thi-Qar | ||
| Article 1, Volume 8, Issue 5, 2013, Pages 36-44 | ||
| Authors | ||
| Mushtaq Talib AL- Safi; Hassan Ressan AL- Rikabi | ||
| Abstract | ||
| myocardial infarction Gets due to lack of oxygen myocardial ischemia emerging from the narrowing of the coronary arteries , where there are several factors that lead to the atheromatous plaque in the artery that block blood flow to part of the heart muscle, including smoking, high blood cholesterol and age. The present study aims to find out the relationship between smoking and loss of genes GSTM1,GSTT1 and the development of heart disease infarction in the province of Dhi Qar. Collected 100 blood samples from patients with myoc- radial infarction admitted to the hospital Hussein teaching and Suq- AL-Suoke general hospital has ranged in age between 20 -79 years old and another 100 samples to people who are not infected with myocardial infarction as a group compared to placed blood samples in tubes contain on the substance EDTA and preserved in 20 - and than extracted of DNA and amplified genes GSTM1 and GSTT1 that is responsible for detoxification and Albumin as a internal control. The results also showed 49% of those infected males and 51% of the females patient while patients in the city 67% compared to 23% for rural and patients who have a family history of 23% compared to 77% does not have a family history The study results showed the existence effectof smoking and lost GSTM1 gene increase the risk of myocardial infarction by three and a half times (OR=3.46 %95 CI 1.125 – 10.682 ) as well as at the loss of two genes together G STM1 and GSTT1 as much as three times )OR = 3 ; %95 CI 0.248 – 36.325) Compared with the comparison group it has contributed to the GSTM1 gene increase risk by (OR = 1.69 % 95 CI 0.681 – 4.202 ) upon comparing patients non-smokers with smokers | ||
| Keywords | ||
| PCR; GSTT; GSTM | ||
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