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Serological Study for TORCH Infections by ELISA Method in Women with Bad Obstetric History in Kerbala City | ||
| Kerbala Journal of Medicine | ||
| Article 1, Volume 6, Issue 2, 2013, Pages 1621-1624 PDF (0 K) | ||
| Authors | ||
| Ban Waheed Hussein; Satar Jabbar Rahi; Alaa Saad | ||
| Abstract | ||
| background: Bad obstetric history (BOH) implies previous unfavorable fetal outcome in terms of two or more consecutive spontaneous abortions, early neonatal deaths, stillbirths, intrauterine fetal deaths, intrauterine growth retardations and congenital anomalies. Maternal infections transmissible in utero at various stages of gestation lead to recurrent pregnancy wastage. Infections caused by TORCH –toxoplasma, rubella virus, cytomegalo virus (CMV) and herpes simplex virus (HSV) – is the major cause of BOH. Objective(S): The study aimed to evaluate the incidence of TORCH infections in women with bad obstetric history (BOH). Patients &methods : The study included 130 women with bad obstetric history and 65 clinically normal women with previous normal full term deliveries who were attended to the gynecological & obstetrical hospital from January to July 2012. Serological evaluation for TORCH infections was carried out by IgM ELISA method. Result: Seropositivity for toxoplasma was 39.23%, rubella 12.3%, cytomegalovirus 35.38% and herpes simplex virus1.53%. Maximum percent cases of abortion (41.37%) Early neonatal death (25%) congenital malformation (16.6%) was associated with toxoplasma infection. Maximum percent of cases of abortion (36.20%) Early neonatal death (25 %) congenital malformation (33.3%) was associated with cytomegalo infection. while (1.72%) and (13.79%) maximum percent of cases of abortion associated herpes and rubella respectively Conclusion(S): TORCH infections are associated with recurrent abortion, intrauterine growth retardation, intrauterine death, preterm labor, early neonatal death, and congenital malformation. Previous history of pregnancy wastages and positive serological reactions during the current pregnancy must be considered while managing BOH cases so as to reduce the adverse fetal outcome. | ||
| Keywords | ||
| BOH; TORCH T toxoplasma; R rubella; CMV cytomegalovirus; H herpes | ||
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