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Evaluation of Immune Response in Patients with Chronic Hepatitis B Infection. II: Humoral Immunity | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 22, Issue 5, 2011, Pages 1-11 | ||
| Author | ||
| Muhammed A. Al-Dabagh | ||
| Abstract | ||
| The humoral immune response play an essential role during hepatitis B virus (HBV) infection .HBV clearance is associated temporally with production of anti-envelope antibodies. The aim of this study was to evaluate the humoral immune response in patient with chronic hepatitis B virus (CHBV) infection via estimation of serum level of interleukin-4 (IL-4),interleukin-6 (IL-6),interleukin-10 (IL-10) and immunoglobulis IgG IgA and IgM .Venus blood samples were collected from 45 patients with CHBV infection. Other 20 blood samples were collected from healthy individuals as control group. Enzyme linked immune sorbent assay (ELISA) was used to estimate the serum levels of IL-4,IL-6 and IL-10.Single radial immuno-diffusion (sRID) assay was used to estimate serum levels IgG, IgA and IgM. The results showed insignificant dropping in serum levels of IL-4 and IgG respectively while there insignificant elevation in IL-6, IgM and IgA respectively ,IL-10 levels shows significant elevation in CHBV patients group as compared with healthy control group. | ||
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