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Evaluation of Immune Response in Patients with Chronic Hepatitis B Infection. I: Innate Immunity | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 22, Issue 5, 2011, Pages 54-66 | ||
| Author | ||
| Muhammed A. Al-Dabagh | ||
| Abstract | ||
| The innate immune system has role not only in protecting the host during the initial period of virus infections but also shaping the nature of adaptive immune response . The aim of this study was to evaluate the innate immune response in patients with chronic hepatitis B virus(CHBV) infection via estimation of serum levels of granulocyte macrophage colony stimulating factor (GM-CSF), interleukin-1alpha (IL-1α), interleukin-8 (IL-8) and complement components C3 and C4. Venus blood samples were collected from 45 patients with CHBV infection. Other 20 blood samples were collected from healthy individuals as control group. Enzyme linked immune sorbent assay (ELISA) was used to estimate the serum levels GM-CSF, IL-1α and IL-8. Single radial immuno-diffusion (sRID) assay was used to estimate serum levels of C3 and C4. The results showed significant dropping in serum levels of GM-CSF and insignificant dropping in C3 and C4, respectively. While there was insignificant elevation in serum levels of IL-1α and IL-8, respectively in CHBV patients group as compared with healthy control group. | ||
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