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Absence of Menstruation(Amenorrhea)Due to Chromosomal Abnormalities | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 22, Issue 5, 2011, Pages 67-75 | ||
| Author | ||
| Wafaa Abdulzahra Kadhim | ||
| Abstract | ||
| Absence of menstruation)amenorrhea) is not a disease but symptom that may results from several causes .Cytogenetic investigation have shown the importance of chromosomal abnormalities as a cause of amenorrhea. The present study aimed at performing chromosomal analysis in patients with primary amenorrhea .Cytogenetic investigations were carried out on 55 women with primary amenorrhea by using GTG-band analysis of metaphases from peripheral blood leukocytes .The karyotypes results revealed 74.5% (n=41) with normal chromosome composition and 25.5% (n=14) showed chromosomal abnormalities .these abnormalities can be classified into three types ,the x chromosome abnormality (including monosomy x , pure x numerical abnormality ,and Turner mosaicism ) was observed in 57.14%(n=8) of all chromosomal abnormalities , the other type of abnormal karyotype in this study is a karyotype showed pure xy female found in only 4 cases (28.5%),and the last type of abnormalities which represented in structural abnormalities of x chromosome in 2 cases (14.2%)one of theme showed marker chromosome and the other case showed deletion of x chromosome. | ||
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