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Effect of Hepatitis C Virus Infection on Lymphocytes Proliferation | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 22, Issue 4, 2011, Pages 1-13 | ||
| Author | ||
| Abbas Arrak Abbas al-Tamimi | ||
| Abstract | ||
| Recovery from viral infection depends mainly on the potential of the cellular immunity. This work was performed to assess the efficiency of T-lymphocytes in control hepatitis C virus infection. Fourten HCV patients included in this study were categorized to two groups according to disease development as assessed by biochemical tests and ultrasound images. Six patients at acute phase or recent infection group and Eight patients at group of chronic phase. Another 10 HCV negative subjects were included as negative control for comparison. Lymphocyte proliferation test was applied on blood obtained from each subject under study using phytoheamagglutinin (PHA) and the mitotic indices were calculated. Statistical analyses were applied using t-test to assess the significance of the differences between samples tested. Results showed: 1- Significant decrease was found in the ability of T-lymphocytes from chronic HCV patients to respond to PHA mitogen compared to acute HCV cases or negative controls. 2- The results were promising towards the ability of determining the stage of disease development depending on the degree of response of T-lymphocytes to the mitogen. | ||
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