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Effect of Melatonin as Antimicrobial Agent Against Some Pathogenic Bacteria | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 22, Issue 4, 2011, Pages 26-38 | ||
| Author | ||
| Suhad F. Hatem | ||
| Abstract | ||
| The widespread distribution of antibiotic resistant bacteria in hospitals specially the types of nosocomial infections caused major public problem which leads to many dead cases .therefore ,our study aimed to evaluate the invitro antimicrobial activity of melatonin against some pathogenic bacteria that isolated from blood, urine,sputum and wounds collected from patient suffered from different clinical cases as follows : (Staphylococcus aureus 4 isolates, Acinetobacter baumannii 4 isolates, Pseudomonas aeuroginosa 2 isolates , Enterococcus faecalis 2 isolates , Pseudomonas aeuroginosa ATCC27853 and Staphylococcus aureus ATCC) . Sesitivity of isolates was tested against some antibiotics, result revealed that isolates showed multi resistant to antibiotics, considered the most important resistant groups was carbepenem resistant P.aeuroginosa and A.baumannii ,methacillin resistant S.aureus and vancomycin resistant E.faecalis . Minimum inhibitory concentration and Minimum bacteriocidal concentration were determined and the results showed that melatonin had antibacterial effects against some pathogenic bacteria , the results obtained that MIC of the melatonin was (64,64,193 ,193,384,384) µg ml against (P aeuroginosa ATCC27853, S aureus ATCC, A.baumannii , P.aeuroginosa ,E.faecalis ,S.aureus )respectively , and MBC of melatonin against (P.aeruginosa ,A.baumannii, S.aureus, E.faecalis, P.aeruginosa ATCC 27835, S.aureus ATCC29123)was (384,384,512,512,128,128) µgml respectively. | ||
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