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Flow-Injection Analysis (FIA) for the Spectrophotometric Determination of Bromhexine Hydrochloride in Pharmaceutical Preparations | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 22, Issue 4, 2011, Pages 134-146 | ||
| Author | ||
| Mouyed Q. Al-Abachi | ||
| Abstract | ||
| Bromhexine Hydrochloride was determined by anew simple and sensitive spectrophotometric method in pure form and pharmaceutical preparations using Flow-Injection analysis. The method is based on the diazotization reaction of Bromhexine Hydrochloride with sodium nitrite in hydrochloric acid medium to form diazonium salt, which was coupled with chromotropic acid to form a red water-soluble azo dye, that has a maximum absorption at λmax=507 nm. All different chemical and physical experimental parameters affecting on the development and stability of the colored product were carefully studied. The FIA procedure sample throughput was 70 h-1, Beer's law was obeyed over the concentration range (30-700 µg.ml-1) with RSD% less than 0.95 % and molar absorptivity of 1.16x104 l.mol-1.cm-1 and Sandell sensitivity of 0.0357 µg.cm-2. The method was applied successfully for the determination of Bromhexine Hydrochloride in pharmaceutical preparations. | ||
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