The Relationship Between IL-10 and Dislipidemia in Type 2 Diabetics

Kadhum Hussain, Majid

	The Relationship Between IL-10 and Dislipidemia in Type 2 Diabetics
Al-Mustansiriyah Journal of Science
Article 1, Volume 22, Issue 4, 2011, Pages 202-213
Author
Majid Kadhum Hussain
Abstract
The current study was designed to estimate the differences in serum interleukin–10 (IL-10) levels in patients with type II diabetes and control group also to demonstrate whether a relationship was indicated among IL-10 and the changes in the levels of lipid and lipoproteins (dyslipidemia) in the same patients. To achieve this aim, 49 diabetic patients (21 females and 28 males) at ages of 47.23±14.23 y were enrolled. To compare the results, 30 healthy individuals (17 females & 13 males) of ages 39.35± 3.89 y were also included as a control group. Serum IL-10 levels were measured in the patients & the control group by an enzyme linked immunosorbent assay (ELISA). Fasting blood glucose level (FBGL) was estimated by the glucose-oxidase method. Total cholesterol, triglyceride and HDL were measured by colorimetric method. The results revealed significantly (P<0.001) decreased of serum IL-10 levels in diabetic patients when compared with those of the control group. Total cholesterol, triglycerides, LDL and VLDL values exhibited significantly (P<0.005-0.0001) elevation in the diabetic patients when compared with those of control group.While HDL level significantly (P<0.0001) decreased in diabetic patients in comparison with those of control group.The linear regression analysis revealed a significant negative correlation for cholesterol (r =-0.45, P<0.001), triglycerides (r =-0.37, P<0.05), LDL (r=-0.30, P<0.05) & VLDL(r=-0.37, P<0.05) level and positive correlation HDL (r=0.49, P<0.001) levels with the IL-10 values in the diabetic patients. Such correlation was not observed for the level of cholesterol, HDL and LDL in control group. Serum IL-10, Total cholesterol, triglycerides &HDL levels were shown to be significantly (r=-0.51, P<0.001, r=0.65, P<0.001, r=0.58, P<0.001, r=-0.49, P<0.05), correlated with FBGL in the diabetic patients but not in control group. In conclusion, low level of IL-10 could be involved in pathogenesis of type 2 diabetes and there is association between IL-10 and dyslipidemia in these patients.

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