of Science, C., Musa Naema Muzher, D., University, K. (2013). The Correlation Study between Serum Concentrations of pro- inflammatory cytokines and acute phase markers in Rheumatoid Arthritis Patients in AL-Najaf Governorate. , 13(2), 17-25.
College of Science; Dr. Musa Naema Muzher; Kufa University. "The Correlation Study between Serum Concentrations of pro- inflammatory cytokines and acute phase markers in Rheumatoid Arthritis Patients in AL-Najaf Governorate". , 13, 2, 2013, 17-25.
of Science, C., Musa Naema Muzher, D., University, K. (2013). 'The Correlation Study between Serum Concentrations of pro- inflammatory cytokines and acute phase markers in Rheumatoid Arthritis Patients in AL-Najaf Governorate', , 13(2), pp. 17-25.
of Science, C., Musa Naema Muzher, D., University, K. The Correlation Study between Serum Concentrations of pro- inflammatory cytokines and acute phase markers in Rheumatoid Arthritis Patients in AL-Najaf Governorate. , 2013; 13(2): 17-25.

The Correlation Study between Serum Concentrations of pro- inflammatory cytokines and acute phase markers in Rheumatoid Arthritis Patients in AL-Najaf Governorate

journal of al-qadisiyah for pure science(quarterly)
Article 1, Volume 13, Issue 2, 2013, Pages 17-25    PDF (0 K)
Authors
College of Science; Dr. Musa Naema Muzher; Kufa University
Abstract
ABSTRACT
Rheumatoid arthritis is a common autoimmune disease of the musculoskeletal
system that is associated with considerable morbidity and diminished quality of life. Serum
samples were obtained from 70 patients with RA who had visited the Division of
Rheumatology at AL-Sadder Teaching Hospital in AL- AL-Najaf City and 25 age- and sex-
matched healthy controls, and the clinical parameters of disease were assessed, including
erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and rheumatoid factor (RF).
Serum concentrations of IL-6, (TNF-α), (IL)-1α, (IL)-8 and serum level of ferritin were
measured using an enzyme-linked immunosorbent assay (ELISA). Serum concentrations of
IL-6, (TNF-α), (IL)-1α, and (IL)-8 were significantly elevated (P<0.0001) in patients with
RA compared to those of healthy controls. Serum levels of ferritin were also significantly
elevated (P<0.0001) in patients with RA compared to those of healthy controls. There were a
good significant correlation between these cytokines and acute phase markers. It has been
concluded that the serum concentrations of IL-6, (TNF-α), (IL)-1α, and (IL)-8 were sig-
nificantly elevated in patients with RA and strongly correlated with acute phase markers.
These findings suggest a possible role for these cytokines in the pathogenesis of RA.
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