Some Hormonal changes in Women With Polycystic Ovary Syndrome (PCOS)

Matter AL-Mhana, Nadia

	Some Hormonal changes in Women With Polycystic Ovary Syndrome (PCOS)
Al-Mustansiriyah Journal of Science
Article 1, Volume 22, Issue 6, 2011, Pages 39-46
Author
Nadia Matter AL-Mhana
Abstract
Polycystic Ovary Syndrome (PCOS) is the most common form of chronic anovulation associated with androgen excess, occurring in 5-10% of reproductive age women. It is also the most common endocrine abnormality in premenopausal women. It is typically presents with amenorrhoea, oligomenorrhoea, hirsuitism and acne, and commonly occurs at mid-twenties of age. It is now known that weight gain in both normal women and those with PCOS is associated with increasing insulin resistance. Most women with PCOS have insulin resistance to a significantly greater extent than in age and body mass index (BMI). In our study, 32(91.4%) of patients with PCOS fall in the age group 15-35 years. In single patients (not married) 29.4% of them suffering over weight and 58.8% suffering obesity, but 55.6% of married patients suffering over weight and 44.4% of them was obesity. There were 28(80%) of patients with positively family history. A significant increase (p<0.05) in Fasting Plasma Glucose (FPG) and C-peptide levels in patients with PCOS (in both single and married) as compared to normal women. In PCOS, the normal pulsatile secretion of LH is increased by an increased frequency and amplitude of pulses, while that of FSH is unchanged or muted, and the LH: FSH ratio can be increased to more than 2.5. There was no significant increase in PRL level (p > 0.05) .We notice that there were a significant increases in progesterone (prog), testosterone (Testo) and Estradial (E2) levels in both single and married patients as compared with normal women (p<0.05).

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