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Study of Plasma Malondialdehyde, Albumin and Bilirubin Levels in Asthmatic Patients as Markers of Oxidative Stress | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 22, Issue 6, 2011, Pages 347-356 | ||
| Author | ||
| Wisamkadhum H | ||
| Abstract | ||
| Asthma is a chronic disorder of the airways with underlying inflammation and oxidative stress. Malondialdehyde (MDA) - the lipid peroxidation product- level increases in inflammatory diseases and used as a common oxidative stress marker. Albumin and bilirubin are components of antioxidant defense system. The aim of this study are, Evaluating oxidative stress as a component of asthma process by measuring MDA (as an oxidative marker), albumin and bilirubin (as biomarkers of antioxidant defense system) in asthmatic patients.Thirty seven asthmatic patients (20 females and 17 males) were involved compared with 37 healthy controls. Plasma samples analyzed for total MDA, albumin and bilirubin. The results of underlying study are: plasma MDA was significantly increased (p<0.05) while plasma albumin and bilirubin were significantly decreased (p<0.05) in asthmatic patients compared to control group.Which lead to conclude that elevated levels of MDA in plasma of asthmatic patients indicate high level of oxidative stress in these patients.Decreasing plasma albumin and bilirubin is due to their consumption and indicate their role as antioxidant species in asthmatic patients. | ||
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