Synthesis of acetylenic mercpto uracil derivatives

M. G. Alzahawy Farah Kh. H. ALjuboory, Hala

doi:10.32894/kujss.2013.87985

	Synthesis of acetylenic mercpto uracil derivatives
Kirkuk Journal of Science
Article 1, Volume 8, Issue 4, 2013, Pages 19-28 PDF (0 K)
DOI: 10.32894/kujss.2013.87985
Author
Hala M. G. Alzahawy Farah Kh. H. ALjuboory
Abstract
Research has included the preparation of compounds of acetylenic mercpto uracil compounds. And for the preparation of these derivatives requests 4 - chloro uracil (1) and can be obtained (1) easily from the reaction of 2,4,6 - trichloro Pyrimidin with a mixture of diethyl aniline and phosphorus oxide, trichloro POCl3, after it has been obtained for compound 4 - Mercpto uracil (2) of the reactant compound (1) Thio urea and reflux the mix in the presence of ethanol and then were treated compound (2)with Propagel bromide to obtain a compound (3) 4 - Propyl thiouracil. On the other reactant compound has (1) with a solution of Mercpto acetic acid (SHCH2COOH) in Sodium hydroxide to obtain compound (5) 2,6 - Dihydroxy-4-pyrimidinyl thio acetic acid and then were treated compound (5) with Propagel alcohol to get propaynyl (2,6-dihydroxy-4-pyrimidinyl thio acetate) (6). and for the preparation of Mannich reaction , Acetylenic compounds (3) and (6) were treated with paraformaldehyde in Isopropyl alcohol and the mixture was heated a bit, then added Secondary amine with Copper chloride with continuous heating to obtain derivatives 4a-e and 7a-e. The purpose of the preparation of these derivatives is to get a new uracil derivatives containing acetylenic amines possible to have a biological effectiveness
Keywords
acetylenic uracil derivatives and mannich bases

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