EFFECTS OF DIFFERENT DOSE OF CYPERMTHRIN ON SERUM ACETYLCHOLINE CONCENTRATION, SPINAL CORD AND SCIATIC NERVE HISTOPATHOLOGY IN ADULT RATS.

Kadem Majeed, Saleh; Jabal Hussein, Talal; Waheed, Zainab

doi:10.33762/bvetr.2014.88131

	EFFECTS OF DIFFERENT DOSE OF CYPERMTHRIN ON SERUM ACETYLCHOLINE CONCENTRATION, SPINAL CORD AND SCIATIC NERVE HISTOPATHOLOGY IN ADULT RATS.
Basrah Journal of Veterinary Research
Article 1, Volume 13, Issue 1, 2014, Pages 116-124 PDF (0 K)
DOI: 10.33762/bvetr.2014.88131
Authors
Saleh Kadem Majeed; Talal Jabal Hussein; Zainab Waheed
Abstract
The present study aimed to investigate the effects of different doses of of Cypermthrin on serum acetylcholine concentration , Spinal cord and Sciatic nerve histopathology in adult rats. Fourty eight adult rats were used , they divided randomly and equally into four groups . Control group orally dosed with normal saline for 90 days . The other three groups were dosed orally with different three doses of cypermthrin , high dose ( 64 mg / kg b.w. ) intermediate dose ( 32 mg / kg b.w. ) and low dose ( 16mg / kg b.w. ). The results shows that serum acetylecholine concentrations increased significantly ( p ≤ 0.05) in rats exposed to high and intermediate dose of cypermethrine compared with control group. Whereas there were no significant difference (p ≥ 0.05) between low dose of cypermethrine and contol group . Hitopathological examination of spinal cord and Sciatic nerve revealed that there were a dose dependent increase in vaccuolation in nerves fibers to be affect larg number of nerve fiber in high dose and it affect few numbers of nerve fibers in low dose. In conclusion cypermthrin affected positively histopathological findinds of nerves fibers .
Keywords
cypermethrin; serum acetylecholine; Rats

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