The Role of Advanced Glycated End Products  and Microalbuminuria on  Developing Diabetic Retinopathy in Type 2 Diabetes Mellitus

Mohammed Juda, Thanaa; Mousa Issa, Ahmed; Kamil Zaidan, Haider

	The Role of Advanced Glycated End Products and Microalbuminuria on Developing Diabetic Retinopathy in Type 2 Diabetes Mellitus
Medical Journal of Babylon
Article 1, Volume 11, Issue 1, 2014, Pages 152-161
Authors
Thanaa Mohammed Juda; Ahmed Mousa Issa; Haider Kamil Zaidan
Abstract
Diabetic retinopathy is a frequent microvascular complication of diabetes mellitus . We analyzed the association of serum level of major advanced glycated end product mainly Nε-carboxymethyl-lysine with prevalence of developing of diabetic retinopathy in Type 2 diabetic patients , a case control study were confirmed on patients with type 2 diabetes mellitus whom were examined by an ophthalmologist at AL- Hilla Teaching Hospital and patients classified into proliferative and non proliferative diabetic retinopathy and the level of Nε-carboxymethyl-lysine were 2.2±0.45 and2.9±0.24 among NPDRP and PDRP respectively and the level among control diabetic patients without retinopathy 1.2±0.2 and the statistical analysis were revealed that were significant difference between patients and control at p value <0.05 Estimation of microalbuminuria among diabetic patients revealed that prevalence of microalbuminuria among patients with NPDRP is (68%) ,and among patients with PDRP are (80%) ,while prevalence among diabetic patients without retinopathy are (33%). The odd ratio for association between microalbuminuria and diabetic retinopathy is calculated and the results is 2.5 which indicate that patients with positive microalbuminuria is at higher risk for developing retinopathy and microalbuminuria is considered risk marker for developing diabetic retinopathy.
Keywords
advanced glycated end products; carboxymethyl; lysine; diabetic retinopathy; proliferative diabetic retinopathy; risk marker; odd ratio

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