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Possible Association of HLA-DR and DQ Molecules with Autoimmune Hepatitis in Iraqi Patients | ||
| Journal of the Faculty of Medicine | ||
| Article 1, Volume 52, Issue 1, 2010, Pages 49-52 | ||
| Authors | ||
| Raghad J H AL-Akayshi; ; ; Eman Sh. AL-Obeidy | ||
| Abstract | ||
| Background: Human leukocyte antigen (HLA) is the most polymorphic genetic system in man. The genes of this region seem to influence susceptibility to certain diseases.Patients and methods: Polymerase chain reaction-Sequence Specific Primers PCR-SSP is the method used to asses HLA-typing of 100 blood samples of 60 AIH patients and 40 healthy normal controls.Results: An increased frequency of HLA-DR3, DR4 and DR7 was observed for patients group versus control group with P-value (0.0001, 0.05, and 0.001) respectively, while DR*0211 (DR2) may be formed the basis for protection against the disease. HLA-DQ on the other hand, yielded on association in Iraqi patients with AIH.Conclusions: This finding demonstrated that HLA-DR3, DR4 and DR7 might play a role in AIH susceptibility.Key words: autoimmune hepatitis, Human leukocyte antigen (HLA), PCR –SSP assay.References: | ||
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