DYSLIPIDEMIA AND OXIDATIVE STRESS IN PATIENTS WITH CHRONIC RENAL FAILURE IN SALAH-ADDIN  PROVINCE

M. Hussain Al-Obaidy, Saad; A. Khedair, Khedair; H. Ahmed Al-Obaidi, Amina

	DYSLIPIDEMIA AND OXIDATIVE STRESS IN PATIENTS WITH CHRONIC RENAL FAILURE IN SALAH-ADDIN PROVINCE
Medical Journal of Tikrit
Article 1, Volume 19, Issue 2, 2013, Pages 203-208
Authors
Saad M. Hussain Al-Obaidy; Khedair A. Khedair; Amina H. Ahmed Al-Obaidi
Abstract
Background: Chronic Renal Failure (CRF) is the state which results from a permanent and usually progressive reduction in renal function, and leads to many complications over a period of time. The most common include cardiovascular, cerebrovascular and peripheral vascular diseases. Oxidative stress is an imbalance between the formation of reactive oxygen species and protective antioxidant defense. oxidative stress increases in chronic renal failure. Measurement of oxidative stress can be done by measurement of parameter malondialdehyde (MDA). The aim of this study was to evaluate dyslipidemia and oxidative stress in chronic renal failure patients by measuring the lipid profile and malondialdehyde, to assess the risk of cardiovascular diseases in CRF patients. Materials and methods: We conducted a cross sectional study for a sample composed of 70 patients with CRF, admitted to the Tikrit teaching hospital, dialysis unit, their ages between 18– 80 years, 40 of cases were male and 30 were female and a control group consists of 45 subjects of comparable age, 24 were male and 21 were female , selected from medical staff who were apparently normal healthy adults without any major illness. Venous blood samples of 5ml were collected from both CRF patients and apparently normal subjects (control) to compare lipid profile and oxidative stress parameter malondialdehyde. The levels of serum triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol l (VLDL-C) and high density lipoprotein cholesterol (HDL) were measured by colorimetric method. TC/HDL-C and LDL-C/HDL-C ratios were calculated. Also, oxidative stress marker MDA was measured by TBA assay method. Results: The levels of serum TG, TC, LDL-C and VLDL-C were significantly increased and HDL-C was significantly decreased in cases when compared to controls. TC/HDL-C and LDL-C/HDL-C ratios were significantly increased in cases when compared to control. Oxidative stress marker, MDA significantly increased in cases when compared to control.

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