The extra efficiency of (five day {zinc & ascorbic acid} drug) course in compares to (One day vitamin A ) course as adjuvant therapy in Measles

D. Moohy Alosy, Baha

	The extra efficiency of (five day {zinc & ascorbic acid} drug) course in compares to (One day vitamin A ) course as adjuvant therapy in Measles
Medical Journal of Tikrit
Article 1, Volume 19, Issue 2, 2013, Pages 339-345
Author
Baha D. Moohy Alosy
Abstract
Background: Measles is a serious infection characterized by high fever, an exanthema, cough, coryza, conjunctivitis. Zinc plays a key role in enzymes and is critical to human growth, metabolism, and immune function Vitamin C is an important antioxidant may affect the functions of the hematopoietic system (immune response, leukocytes, macrophages, red blood cells) Aims: prospectively studied to assess the effect of both treatment groups on Clinical Manifestation (Typical) (Atypical) of Measles & assess the effect of both treatment groups on clinical course (Typical) duration and Radiological improvement days Patients and Methods: Sexhandred Child less than 15 years of age present with Measles. In my private clinic& outpatient clinic of pediatrics department in Tikrit teaching Hospital were admitted and collected from October 2006 to December 2010 Sub classified as 400 Child (five day drug) group and 200 Child (One day vitamin A ) group were schedule to receive (specific dose twice daily) while vitamin A (Single dose of 200,000 1U orally for Child under 15 yr of age /100,000 IU for children 6 mo to 1 yr of age ), A chiefly planned questionnaire was used to collect information about The effect of drug on natural clinical course and for more precise data Sub classified Clinical Manifestation into typical as (coryza, koplikSpote, conjunctivitis, photophobia , high fever, mild fever, cough, milder maculopapular , severe maculopapular, desquamation (( and Atypical Manifestation of Measles as (Febrile seizures, delirium, abdominal pain, vomiting, bloody diarrhea, pneumonia, pleural effusions). Results: The estimates of Typical AND A Typical Clinical Manifestation were significant lesser degree in (five day drug) { Typical 3.0642 AND A Typical 0.0112} than { Typical 5.172 AND A Typical 0.0233} for (One day vitamin A ) & The effect on natural clinical course & on Radiological improvement days (five day drug) group (0.80719), (0.5556) less than in (ONE day) group (1.41022) (1.3913) CONCLUSIONS: This study indicates the extra efficiency of (five day {zinc & ascorbic acid} drug) course in compares to (One day vitamin A ) course as adjuvant therapy in Measles. The outcome are planned to generate novel hypotheses for clarifying zinc &ascorbic acid as adjuvant therapy in Measles
Keywords
Measles; Zinc; vitamin C

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