Combined Deferoxamine - Deferasirox In Treatment Of Thalassemia Major With Iron Overload

Kareem A. Mahmood, Abdul; Almadany, Talib

	Combined Deferoxamine - Deferasirox In Treatment Of Thalassemia Major With Iron Overload
kufa Journal for Nursing sciences
Article 1, Volume 4, Issue 1, 2014, Pages 99-105
Authors
Abdul Kareem A. Mahmood; Talib almadany
Abstract
Aim :to assess the efficacy and safety of combined Deferoxamine-defeosiraxregime and deferasiraox alone in group of thalassemia major patients Patients and Method: Fortytwo patientsstudied for one year.,29 patients of Deferoxamine (20mg/kg/day infusion ,two days /week) and Deferasiraox. Efficacy of both regimes assessed by serum ferritin. safety assessed by liver enzyme, creatinine and blood urea. Results: Those patients who were on Deferasiraox alone showed significant them chosen fordeferasiraox (40 mg/kg/day),13 patients combinedtherapy reduction of serum ferritin (4482), to meanof serumferritin (3132±336) range (595-8743 ng/l).The study clarified no significant changes in liver enzymes and blood urea, fortunately decline in (ALT), from mean value of (82_+16IU), tomean value (56_+6IU). Conclusion: combined Deferosirax-Desferoxamine therapy is effective regime to maintained negative iron balance owing to more time iron chelation coverage, and acceptable compliance. Recommendation:-more clinical trial therapy needs to be done on larger group of patients, and for longer period of time to insure the safety of combined therapy.Deferasirox till now proved to be effective and safe enough to be used with great deal of compliance for patients with iron over load.
Keywords
iron over load; chelation; thalassemia

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