A NEW FORMULATION OF PENTAVALENT 99MTC-DIMERCAPTO SUCCINIC ACID

	A NEW FORMULATION OF PENTAVALENT 99MTC-DIMERCAPTO SUCCINIC ACID " 99MTC (V) DMSA" FREEZE-DRIED KIT FOR SKELETON SCINTIGRAPHY
Iraqi Journal of Biotechnology
Article 1, Volume 9, Issue 1, 2010, Pages 105-114
Abstract
A new formulation of Sn-2,3meso dimercapto succinic acid“Sn-DMSA" kit to be labeled with penta valent technisum-99m. The DMSA kit was prepared by simple and fast procedure. It was prepared by reaction of kit that is contained (1.2mg 2,3 meso dimercapto succinic acid, 0.4mg stannous chloride dihydrate, 50mg of Inositol and 1.0mg of ascorbic acid as anti oxidant ) with Na99mTcO4 at pH equal to 8.0 which is the optimal condition of the formation of 99mTc (v) DMSA complex the radiochemical yield and the stability of kit in liquid and lyophilized forms were determined by using gel filtration column scanning "GCS". The radiochemical yield of complex formation was greater than 99% after 15min. from addition of Na 99mTcO4. The complex in liquid form was stable during six hours while the lyophilized form for six months. Biodistribution of 99mTc(v)DMSA in New Zealand white rabbits demonstrated greater uptake in bone marrow and liver 50% and 40% while lower uptake in liver 6.2% during one an hour after injection respectively, however a negligible amount of radioactivity was detected in the non target organs. The study suggests that this kit was an excellent agent for skeleton and bones scintigraphy which was used in diagnosis and scanning of metastases.
Keywords
Dimercapto succinic acid; Freeze; dried kit; GCS; Skeleton

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A NEW FORMULATION OF PENTAVALENT 99MTC-DIMERCAPTO SUCCINIC ACID " 99MTC (V) DMSA" FREEZE-DRIED KIT FOR SKELETON SCINTIGRAPHY