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Effect of carbamazepine and valproic acid monotherapy on thyroid function tests in epileptic patients | ||
| Annals of the College of Medicine, Mosul | ||
| Article 11, Volume 32, Issue 1, 2006, Pages 57-62 PDF (0 K) | ||
| DOI: 10.33899/mmed.2006.8903 | ||
| Authors | ||
| Imad A. Thanoon; Ashraf H. Ahmed | ||
| Abstract | ||
| Objectives: This study was conducted to assess the effect of carbamazepine (CBZ) and sodium valproate (VPA), as a monotherapy in epileptic patients, on thyroid function tests as assessed by serum total triiodothyronine (TT3), total thyroxine (TT4) and thyroid stimulating hormone(TSH). Subjects and methods: Sixty three epileptic patients using monotherapy were included in the study. These included 44 patients using CBZ and 19 using VPA. A control group of 47 apparently healthy individuals were also included in the study for comparison. Measurement of TSH, TT3 and TT4 was done using Gamma counter.Results: The results of this study revealed that patients on CBZ showed significantly decreased mean level of TT4 in comparison with the control group (P<0.01), while mean TT3 and TSH levels showed statistically insignificant differences from the control group (P>0.05). In the VPA group, mean TT3, TT4 and TSH values showed insignificant differences from the control group (P>0.05).Conclusion: Unlike VPA, CBZ significantly decreases level of TT4 without affecting TT3 and TSH levels. Keywords: Carbamazepine, sodium valproate, thyroid function tests. | ||
| Keywords | ||
| Carbamazepine; Sodium Valproate; thyroid function tests | ||
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