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EFFECT OF 1% HYDROGEN PEROXIDE (H2O2) IN DRINKING WATER ON SOME PARAMETERS IN ِِADULT MALE RABBITS | ||
| Iraqi Journal of Biotechnology | ||
| Article 1, Volume 9, Issue 2, 2010, Pages 202-210 | ||
| Abstract | ||
| The present study was undertaken to investigate the effect of 1% of H2O2 on some biochemical markers related to oxidative stress,cardiac, hepatic and thyroid functions in adult male rabbit's.Twenty adult male rabbits were divided randomly into two groups (10/group), the first (control) group and the second (T) group: animals were received 1% hydrogen peroxide (H2O2)in drinking water for one month.At the end of the experiment, fasting blood samples were drawn by cardiac puncture technique from all experimental animals for measuring : a- serum concentration of total cholesterol(TC);triacylglycerol( TAG);low density lipoprotein –cholesterol( LDL-C) ;very low density lipoprotein –cholesterol (VLDL-C) and high density lipoprotein –cholesterol (HDL-C) b- serum alanine transaminase (ALT) ;aspartate transaminase (AST) and lactate dehydrogenase (LD) activities c- albumin and globulin concentrations. d-Platelets count and prothrombin time e-serum glutathione (GSH) and malondialdehyde (MDA) concentrations. F-serum thyroid stimulating hormone (TSH), triiodothronine (T3),tetraiodothyronine(T4) and glucose concentrations. The results revealed that male rabbits receiving 1% H2O2 in drinking water for one month showed a significant increase(p<0.01) in serum TC, TAG, LDL-C, VLDL-C and MDA concentrations, ALT, AST and LD activities and platelets count, and a significant decrease (p<0.05) in serum HDL-C, GSH, albumin, globulin concentrations and prothrombin time comparing to control, besides significant decrease (p<0.05) in serum T3 & T4 and significant increase (p<0.05) in serum TSH, and glucose concentration were observed. On conclusion, it has been found that exposure to1% H2O2 of exerts deleterious effect on cardiac and hepatic functions, hypothyroidism and state of oxidative stress. | ||
| Keywords | ||
| hydrogen peroxide; Lipoproteins; Thyroid hormones; liver enzymes | ||
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