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Pathophysiological consequences of acidaemia and alkalaemia on the biodistribution of a selected group of Technetium-99m radiopharmaceuticals. | ||
| journal of kerbala university | ||
| Article 1, Volume 7, Issue 4, 2011, Pages 84-89 PDF (0 K) | ||
| Authors | ||
| Jameel M.Badi; Hassan M. Resen; Hisham .M.A.K.Al-Azzawi; Mustafa M.Abd Al razak | ||
| Abstract | ||
| Actively induced acidaemia and akalaemia have been achieved in male Swiss albino mice by the intraperitoneal injection of a known dose solutions (10mgkg) of either NH4Cl or NaHCO3 solutions) for 5, 10 and 15 minutes, prior to administration of labeled agents (99mTc-Tin-colloid, 99mTc-DTPA, and99mTc-HIDA). Applied for liver, kidney, and hepatobiliary system radiodiagnosis of treated animal were compared with results of biodistribution data of the control group. The results of biodistribution data of acidaemic animals (blood pH range 6.8-6.9) have shown no significant difference in the liver uptake when99mTc-Tin-colloid applied .Whereas, acidaemic animals have shown a significant(p<0.05) in the renal uptake at 10 mints period ,when injected with 99mTc-DTPA. As well as these animals have shown a significant deferent (p<0.05) in the excretion behavior of 99mTc-HIDA from liver to intestine. The results had shown a normal biological distribution of three scanning labeled agents in alkalaemic animal (blood pH range 7.7-7.8). | ||
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