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Immunoenhancing Properties of Thymosine and Immunoferron on Leishmania donovani Pathogenicity In Experimental Animals | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 18, Issue 1, 2007, Pages 1-13 | ||
| Author | ||
| Hadi R. Hassan Al-Masudi | ||
| Abstract | ||
| Golden hamsters (Mesocricetus auratus) were treated intraperitoneally with 20μg of semipurified thymosine and 10μg of immunoferron for six successive days, then infected with 5x106 promastigotes of L. donovani. After 60 days post infection, the number's of total parasite burden, spleen and liver indices, delayed type hypersensitivity and histopathological changes in spleen and liver were investigated. The total parasites burden, liver and spleen weight were lower (P<0.01) than untreated, while the average of DTH was higher than (P<0.01) untreated one. Also, the histopathological change for spleen and liver less effect than untreated control. The result of investigation indicated that the semi purified thymosine and immunoferron activate the immune system against visceral Leishmaniasis. | ||
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