Correlation between T-lymphocytes cytokines level and immune response to hepatitis B virus  vaccine

	Correlation between T-lymphocytes cytokines level and immune response to hepatitis B virus vaccine
journal of kerbala university
Article 1, Volume 7, Issue 4, 2011, Pages 42-49 PDF (0 K)
Abstract
Hepatitis B virus (HBV) infection is a major public health problem and its outcome depends on the kinetics of the virus host interaction and in particular on the strength of the immune response. This study was done to illustrate some immunological in vaccinees and effectiveness of HBV vaccine in vaccinees groups . This study was conducted from September , 2011 to October, 2012. ELISA assay was used for detection of hepatitis B virus surface antigen as well as anti hepatitis B-core antigen . This study was also include measurement of anti- HBsAg level to detect the immune response in vaccinees . It was found that significant differences in the antibodies levels according to post vaccination periods and the highest antibodies level in male and female was reached after 90 days post 3rd dose of vaccination , it was 124.85 mIU/ml and 155.94 mIU/ml in male and female respectively. There was also significant differences in ( IL-4 and INF-α ) cytokines it was found that the highest level of IL-4was 12.95pg/ml and 13.23pg/ml in male and female respectively 90 days post 3rd dose of vaccination. On the other hand the highest level of IFN-α was reached 12.60pg/ml in male which was detected 60 days post 3rd dose of vaccination. Whereas it highest level in female was reached to 15.60pg/ml was detected 90 days post 3rd dose of vaccination .

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