The role of high dose of Pomegranate on P53 expression in healthy and Dacarbazin’s treated experimental male rats

Q. Othman, Goran; S. Al-attar, Mustafa; K. Bakir, Firas

	The role of high dose of Pomegranate on P53 expression in healthy and Dacarbazin’s treated experimental male rats
Iraqi Journal of Cancer and Medical Genetics
Article 1, Volume 4, Issue 1, 2011, Pages 35-39
Authors
Goran Q. Othman; Mustafa S. Al-attar; Firas K. Bakir
Abstract
The possible action of high dose of pomegranate (Punica granatum L.) powder extract was evaluated in normal healthy and dacarbazine-induced toxicity in albino rats. Twenty-eight male albino rats were used in this study. The animals were divided into three different groups in addition to control group. The first group treated with intravenous injection of (1mg/kg b.w.) dacarbazine. he rats of the second group supplemented with pomegranate juice with concentration (1000mg/l) in drinking water, while the third group was the combination of the two treatments. Samples of blood were collected after a weeks of treating, and the serum was obtained in the laboratory for the evaluation of P53 protein within the serum. The results showed a significant reduction of P53 level in dacarbazine treated rats comparing with control. Whereas, pomegranate juice treated rats had significant increasing of P53 level as compared to control. The level of the combination treatment also was significantly more than control and dacarbazine treatment, while it was significantly lesser than pomegranate juice treated rats. These finding suggests that dacarbazine cytotoxicity is not P53 dependent and high dose of pomegranate has role in P53 protein expression induction.
Keywords
Dacarbazine; Pomegranate

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