Synthesis, Characterization and Study Biological activity of some New 1,3-Oxazepine and 1,3-Diazepine derivatives

W. Adam, Ruaa; Ezzat.H.Zimam,

	Synthesis, Characterization and Study Biological activity of some New 1,3-Oxazepine and 1,3-Diazepine derivatives
karbala journal of pharmaceutical sciences
Article 1, Volume 5, Issue 7, 2014, Pages 195-217 PDF (0 K)
Authors
Ruaa W. Adam;
Abstract
New 1,3-oxazepine and 1,3-diazepine derivatives containing azo group have been prepared. The first step,(O-tolidine) was converted to [3,3`-dimethyl-(1,1`-biphenyl) -4,4`-diyl) bis (diazene-1,2-diyl))bis(naphthalene-2- amine)] Azo O-tolidine[A].by Azotization reaction with naphthyl amine. The second step, amine group of the azo derivative [A] was condensed with different aromatic aldehydes[p-dimethyleaminobenzaldehyde, 4-chlrobenzaldehyde,4-nitrobenzaldehyde,4-bromo benzal dehyde , 4-hydroxy-3-methoxybenzaldehyde] in the presence of absolute ethanol to give new azo Schiff bases derivatives [B-F] respectively. Then, the resulting imines derivatives [B-F] were reacted with maleic anhydride and phathalic anhydride in dry benzene to give new 1,3-oxazepine-4,7-dione ring derivatives [Ba-Fa] , [Bb-Fb] , all these compound reaction with sulphadiazene to producte 1,3-diazepine-4,7-dione ring derivatives [Ba1-Fb2]. Also study the Biological activity to this derivatives ; All prepared compounds were characterized by melting points and FT.IR spectroscopy, some of them are characterized by 1H-NMR spectroscopy and C.H.N analysis.
Keywords
Ortho tolidine; Azo compound; Schiff bases; oxazepine; Diazepine; Biological activity

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