Incidence of Epstein Barr Virus infection in newly diagnosed non-Hodgkin lymphoma in the national center of hematology-single center study

Fadhil Alwan, Alaa; Karim Al- Rahal, Nidal; Ahmed Shabeeb, Zeyad

	Incidence of Epstein Barr Virus infection in newly diagnosed non-Hodgkin lymphoma in the national center of hematology-single center study
Iraqi Journal of Cancer and Medical Genetics
Article 1, Volume 7, Issue 1, 2014, Pages 21-25
Authors
Alaa Fadhil Alwan; Nidal Karim Al- Rahal; Zeyad Ahmed shabeeb
Abstract
Background: Non Hodgkin lymphoma (NHL) is a diverse group of disorders both in their original history and in response to therapy .The appearance of Epstein-Barr infection (EBV) in Non-Hodgkin’s lymphoma (NHL) could be distinguished by enzyme link immune sorbent assay by detecting IgM and IgG. The role of EBV as causative agent for non-Hodgkin lymphoma has been supported by identification of large amounts of latent membrane protein 1 (LMP-1) outflow in tumors. The aim: of this study was to determine the incidence of EBV infection in patient with newly diagnosed patients with non-Hodgkin lymphoma. Materials and Methods: This study was done at the Department of clinical hematology, the national center of hematology (NCH), Baghdad, Iraq from August 2012 to November 2013. It is a prospective study. A total of 56 patients with age ranged from 18 – 56 years were included. They were diagnosed with NHL and then classified to subtypes by studying histopathology and immunohistochemistry. Assessment of EBV IgM and IgG were done by ELISA technique. A second group comprised of 22 patients with non-malignant condition regarded as control group with matched sex and age. Statistical analysis was performed utilizing SPSS version 17.0. Result: Mean age of the patients was 51.44±15.93 years. Thirty-six (70.4%) were males and 20 (29.6%) were females. Seven (12.5%) out of 56 cases were positive for EBV–IgM, two cases (28.5%) were follicular lymphoma, 5 cases (71.5%) were diffuse large B cell lymphomas. For the EBV-IgG 12 patients (21.4%) were negative while majority 44 patients (78.6%) were positive, in comparison to control group the result was statistically not significant. Conclusion: This study showed that the age, sex and clinical characteristics of Iraqi patients with NHL are different from those of surrounding countries and. The incidence of EBV is high in NHL. The most frequent subtype of NHL is diffuse large B cell lymphoma.
Keywords
Incidence; Epstein; Barr virus; NHL

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