Impact of Aging on Some Hormonal Parameters in Human Males

Ghani Omran, Dakhel

	Impact of Aging on Some Hormonal Parameters in Human Males
Journal of University of Babylon
Article 1, Volume 22, Issue 6, 2014, Pages 1780-1785
Author
Dakhel Ghani Omran
Abstract
Substantial and important age related change occur in the several hormones such as TSH, T3, T4, cortisol, and testosterone. Physiological aging is an extremely complex, Multiofactorial process, affecting a myriad of genetic, biochemical, and metabolic processes. The present study conducted to evaluate the hormonal disturbances that occurring at advanced age stages. The results of thyroid hormones, showed a significant decrease (P<0.05) in the levels of thyroid stimulating hormone (TSH) with significant increase. (p<0.05) in the levels of triiodothyronine (T3) and levels of tetraiodothyronine (T4) in aging human males in a comparison with young human males. Concerning the levels of testosterone and cortisol hormone showed a significant decrease (P<0.05) of aging human males when compared with young human males. Antioxidants levels (such as reduced glutathione and catalase), also involved in this study and their results reported significant decrease (P<0.01) of aging males human when compared with young human males. Data obtained from this study may attributed that at advanced age may be the DNA damage causes the cells to stop dividing or induce apoptosis, often affecting stem cell pool and hence hindering regeneration. Thus, DNA damage is thought to be the common path way causing aging , Hormones and cancer.
Keywords
Hormones; cancer; Aging

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