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Effect of the antibiotics on the L-asparaginase purified from environmental serratia plymuthica | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 16, Issue 1, 2005, Pages 1-11 | ||
| Author | ||
| sahira N. muslim | ||
| Abstract | ||
| Tow simple, accurate and sensitive spectrophotometric methods are proposed for the determination of imipramine-HCl in pure form and in pharmaceutical tablets. The first method is based on the formation of charge-transfer complexes between the drug base as an n-donor and 2,3- dichloro-5, 6-dicyano-p-benzoquinone (DDQ), p-chloranilic acid (p-CA) and p-chloranil (p-CL) as Π-acceptors. The colored products are measured spectrophotometrically at 450, 500 and 540nm for DDQ, p-CA and p-CL, respectively. Beer’s law is obeyed in a concentration range of 8-70 μg/ml for the complex with DDQ and 10-50μg/ml for both complexes with p-CA and p- CL. The molar absorpitivites are found to be 3.945x103, 1.67x103 and 0.323x103 l.mol-1 cm-1 for DDQ, p-CA and p-CL, respectively. The second method is based on the extraction of the formed ion – association complexes of the drug with either thymol blue or bromophenol blue at pH values 4.16 and 3.60, respectively. The products exhibit absorption maxima at 415 and 410nm for thymol blue and bromophenol blue, respectively. Beer’s law is obeyed in a concentration range of 50-250 and 20-60μg/ml with molar absorpitivites of 0.7795x103 and 1.742x103 l.mol-cm-1 for thymol blue and bromophenol blue, respectively. | ||
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