Antibacterial Activity Of Novel Derivatives Compounds Containing 1,2,3-Seleniadiazole Heterocyclic Ring Against Some Pathogenic Bacteria

Sabbar  Al-Rubiae, Muna; Ali  Al- Hilli, Luma; J. Baqir, Sadiq; N. A. Jafar, Nadhir

	Antibacterial Activity Of Novel Derivatives Compounds Containing 1,2,3-Seleniadiazole Heterocyclic Ring Against Some Pathogenic Bacteria
Journal of University of Babylon
Article 1, Volume 22, Issue 7, 2014, Pages 1943-1946
Authors
Muna sabbar Al-Rubiae; Luma Ali Al- Hilli; Sadiq J. Baqir; Nadhir N. A. Jafar
Abstract
In the previous study three compounds of semicarbazones (namely, 2: 1-Naphthalen- 1-yl-etylidene-urea, 7a: 1-{4[6-(4-Acetyl-phenoxy)-hexacyloxy]-phenyl}-ethanone Bis, 7b: 1-{4[12-Acetyl-phenoxy)–dodecyloxyl-phenyl}-ethanone Bis) were used to prepare three novel 1,2,3-seleniadiazole heterocyclic ring compounds respectively (namely: (3) :4-naphthalene-1-yl-[1,2,3]selenadiazole, (8a) : 1,6-Bis[4-(1,2,3-seleniadiazol-4-yl) phenoxy] hexane, (8b): 1,12-Bis[4-(1,2,3-seleniadiazol-4-yl) phenoxy] dodecane). We described here the antibacterial activity of semicarbazones compounds and the new series of compounds containing 1,2,3-seleniadiazole heterocyclic ring. The compounds 2, 7a, 7b, 3, 8a, 8b were evaluated in vitro for their antibacterial activity against three genera of Gram negative bacteria; Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and two of Gram positive bacteria, Staphylococcus aureus, S. epidermidis. The novel 1,2,3-seleniadiazole heterocyclic ring compounds (3,8a, 8b) showed very good activity against gram positive bacteria (Staphylococcus aureus, S. epidermidis) and showed moderate antibacterial effect against gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia), whereas the semicarbazones compounds (2, 7a, 7b) had not any effect on all types of bacteria in this study.
Keywords
Key Words; seleniadiazole; the antibacterial activity

Statistics Article View: 39 PDF Download: 17