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Synthesis of New 3,4-Dihydropyrimidine-2-(1H)-one Derivatives | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 18, Issue 2, 2007, Pages 38-50 | ||
| Author | ||
| Redha I. H. AL-Bayati | ||
| Abstract | ||
| Condensation of 4-chloro benzaldehyde and urea with ethyl acetoacetate in the presence of LaCl3.7H2O gave a quantitative yield of ethyl 4-(4-chloro phenyl)-6-methyl-2-oxo-1,2,3-4-tetrahydro pyrimidine-5-carboxylate (1). Reaction of compound (1) with hydrazine hydrate resulted carbohydrazide derivative (2). Interaction of (2) with ethyl acetoacetate, CS2/KOH (r.t.) 16 hrs, CS2/KOH, Δ, 7 hrs, C6H5COOH/POCl3, HCOOH and phenyl isothiocyanate afforded new 3,4-dihydropyrimidine-[1H]-2-one derivatives (3-8). The compound (8) was converted into 3,4-dihydropyrimidine-[1H]-2-one derivatives comprising 1,2,4-triazole (9) and 1,3,4-thiadiazole (10) moieties. The characterization of the products have been done on the basis of some spectral data (IR, UV) | ||
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