Study of Some Miswak (Salvadora persica L) Components and Effect of  Their Aqueous Extract on Antioxidant

Taha Mohammed, Mustafa

	Study of Some Miswak (Salvadora persica L) Components and Effect of Their Aqueous Extract on Antioxidant
Iraqi Postgraduate Medical Journal
Article 1, Volume 13, Issue 1, 2014, Pages 55-60 PDF (0 K)
Author
Mustafa Taha Mohammed
Abstract
ABSTRACT: BACKGROUND: Oxidative stress defines that, the level of Reactive Oxygen Species (ROS) exists in excess of antioxidant defenses. This imbalance in the redox milieu results in a switch from ROS-stimulated ambient signaling processes to ROS-mediated pathophysiological consequences. Oxidative stress has been implicated in the installation and progression of several degenerative diseases via DNA mutation, protein oxidation and/or lipid peroxidation. Therefore, possible use aqueous extracts of Miswak to protect brain against the Lipid peroxidation. OBJECTIVE: The present study was undertaken to evaluate the potential of Salvadora persica L. (miswak) against the DPPH Free Radical Scavenging System and Lipid peroxidation. METHODS: The chemical components of the prepared aqueous extracts of Miswak were detected as: glycosides, alkaloids, saponins, phenolic compounds, tannins, flavonoids , proteins ,steroids and Vitamine C. and then estimate DPPH Free Radical Scavenging System and Lipid peroxidation RESULTS: The study showed that the Miswak ( Salvadora persica L.) in the aqueous extracts contain : glycosides , proteins, saponins ,tannins ,phenolic compounds, flavonoids , alkaloids , steroids and vitamine C . Aqueas extracts were found effective in scavenging DPPH(62.45℅) in concentration (250µl/ml), as well as inhibiting the lipid peroxidation (42.04℅). CONCLUSION: Our results suggest that Miswak ( Salvadora persica L.) treatment protects the rat brain against lipid peroxidation and DPPH free radical scavenging. .
Keywords
KEY WORDS; DPPH; lipid peroxidation

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