Effect of zinc in some biochemical parameters in male rats  exposed to oxidative stress

M. Kareem, Hussein; IhsanR.Ibrahim,

	Effect of zinc in some biochemical parameters in male rats exposed to oxidative stress
Journal of College of Education for Pure Science
Article 1, Volume 4, Issue 1, 2014, Pages 371-383
Authors
Hussein M. Kareem;
Abstract
This study investigated the effects of zinc sulfate on biochemical parameters in male rats treated with hydrogen peroxide .Animals were divided into five groups (5 animals for each group )The first group was group C as negative control group and was given only water drinking and the second group G1 which given only hydrogen peroxide and considered as positive control group while other groups G2, G3, G4 were given orally concentrations of zinc( 25,50,75 mg / kg) respectively, at the same time hydrogen peroxide was given in drinking water for 15 days. At the end of experiment the concentrations of total cholesterol (TC), Triglycerids (TG), high-density lipoprotein (HDL-C),very low density lipoprotein (VLDL-C) and Atherogenic index, as well as antioxidant and oxidant glutathione(GSH) and malondialdehid.(MDA)were measured. Results of the current study showed significant increase(P <0.05) in the levels of (TC), (TG), (VLDL-C) , Atherogenic index and in the level of lipid peroxidation ((MDA) while there was a significant decrease (P < 0.05) in (HDL-C) and glutathione (GSH) in animals which given H2O2 , while the groups G4, G3, G2 have significant improvement in the studied parameters and this improvement is related to simultaneous adminstration and quantity of the Zn dose also the results showed that treatment of zinc with hydrogen peroxide at dose of 50 mg / kg has the best results .

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