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The protective role of green tea beverage in decrease the side effects of Doxorubicin drug in some biochemical and liver tissue in Male domestic rabbits | ||
| Journal of Tikrit University For Agriculture Sciences | ||
| Article 1, Volume 14, Issue 2, 2014, Pages 295-306 | ||
| Authors | ||
| Mowafaq M.Z . Al-Iesawi; Zaid M.M. AL- mahdawe; Saleh M.R | ||
| Abstract | ||
| The study included the test of protective role of green tea in reduce the side effects which happened by using Doxorubicin anticancer drug on some Biochemical and histological changes in rabbits male adults . The rabbits distributed to four groups , 1 st group fed with normal diet only , 2 nd group fed with diet and injected ( 10 mg / kg ) of Dox . ( one dose weekly ) , 3 rd group fed diet and ( 15 mg / kg ) of Dox ( one dose weekly ) and 4 th group fed diet and treated with ( 15 mg / kg ) weekly and fed with 20 ml / kg of green tea beverage daily , this experience continued for one month . The results revealed that treated with Dox caused high significant increase ( p ≤ 0.01 ) in malondialdehyde ( MDA ) in animal sera the feeding green tea beverage caused high significant ( p ≤ 0.01 ) in (MDA ) by reduse the side effect of Dox Who caused free radicals in 4th group as antioxidant decrease the concentration of MDA . Also the results showled significant decreases (p ≤ 0.01 ) in Glutathione ( GSH ) in serum of animal exposure a oxidation stress caused by Dox ( 10 and 15 mg / kg of B.W ) campared with control . the treatment of 4 th group animal with the green tea beverage showled high significant increase (p ≤ 0.01 ) of glutathione concentration . Also the results revealed strong effect of the green tea beverage in redusing the activity of Alkaline phosphates ( ALP ) . The results shouled high significant (p ≤ 0.01 ) increase in activity of Aspartate amino transferase ( AST ) and Alanin amino transferase ( ALT ) when the group treated with Dox . while the treated of the green tea beverage with the ( 4 th groups ) the results shouled high significant (p ≤ 0.01 ) in reduse the effect of Dox . The histological sections revealed clearly improvement in liver tissue ( which treated with the green tea beverage ) . This indicate that the green tea have aprotective role to decrease the side effects caused by use Dox . and in the same time this consedere as Antioxidant Material . | ||
| Keywords | ||
| green tea; Doxorubicin; Free Radicals; Antioxidants | ||
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