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Study for infection rates of Epstein – Barr virus in thyroiditis patients | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 25, Issue 2, 2014, Pages 31-36 | ||
| Author | ||
| Abbas Arrak Abbas | ||
| Abstract | ||
| Human thyroditis is a common inflammatory group of disorders and categorized to different types according to the etiological agents and clinical and immunological status. In this study, Epstein – Barr virus had been investigated as a possible causative agent of thyroditis since this virus is related to Herpesviridae group there members are known as causative agents of tumors and latent infections. We investigate of presence of EBV infection in fourteen thyroditis patients (as confirmed by the abnormality in their T3, T4, TSH levels) by detection antibodies against some viral antigens ( VCA-IgM, VCA- IgG, EBNA-1 IgG) in patients serum samples matched against thirty three random samples taken from healthy individuals with normal T3, T4, TSH levels as control group. This study showed the presence of two (14%) EBV past infection in thyroditis patients compared to six (18%) positive cases in control group while the infection rate in the whole cases was 17%. The study showed nonsignificant differences between thyroiditis patients and healthy control which may be attributed to the fail of anti-EBNA antibodies developments in certain patients. Thus, the need for thyroid tissue biopsy and advanced technique such as PCR is necessary to assess the definite role of EBV in the pathogenesis of thyroditis. | ||
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