Effect of Alcoholic Catechin Extract on Hyperglycemia,    Hyperlipidemia and Liver Functions in Alloxan Diabetic Mice

K. Ghudhaib, Kadhim

	Effect of Alcoholic Catechin Extract on Hyperglycemia, Hyperlipidemia and Liver Functions in Alloxan Diabetic Mice
Baghdad Science Journal
Article 1, Volume 11, Issue 3, 2014, Pages 1192-1200
Author
Kadhim K. Ghudhaib
Abstract
The objective of this study is to estimate the effect of the hydro-ethanolic catechin extract toward blood glucose, lipid profile and liver functions in alloxan diabetic mice. 50 healthy mice (25-30 g) were divided into five groups of ten animals for each. Group A received normal saline as normal control group. To induce diabetes, alloxan (150 mg/kg), intraperitoneal (i.p.) single dose was injected to groups B, C, D and E. Group B represents diabetic control group. Groups C, D and E received ethanolic catechin extract (30 mg/kg and 40 mg/kg) for different periods of 1, 2 and 3 weeks as treated groups. Blood glucose, serum lipids [Total Cholesterol (TC), Triglycerides (TGs) and High Density Lipoproteins (HDL)], asparagine transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) were estimated after one, two and three weeks. Group B showed a significant increase in blood glucose, TC, TGs, AST, ALT and ALP as compared to group A. Groups C, D, and E showed a significant decrease in mentioned serum biochemical parameters in comparison to group B. In contrast, groups C, D and E showed significant increase in serum HDL as compared to B group. The results clearly revealed that ethanolic catechin extract possesses significant antihyperglycemic and antihyperlipidemic activities together with its ability to improve liver functions in alloxan diabetic mice.
Keywords
Catechin extract; Alloxan diabetic mice; Hyperglycemia; Hyperlipidemia

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