Effect of aqueous extract of Coriandrum sativum seeds on some functional and biochemical blood standards  in males diabetic   rabbits

	Effect of aqueous extract of Coriandrum sativum seeds on some functional and biochemical blood standards in males diabetic rabbits
journal of kerbala university
Article 1, Volume 10, Issue 1, 2014, Pages 34-48 PDF (0 K)
Abstract
This study aimed to determine the effect of aqueous extract of coriander seeds on some physiological and biochemical indicators in male rabbits that have induced diabetias by alloxan . The study was conducted in the Animal 's house Department of biology in the College of Education for Pure Science - University of Kerbala for the period from the May 2013 until October 2013 , 25 male local rabbits were used by alloxan and randomly divided into five groups (5 animals per group) the first group G1 a group of control and administration daily with a solution of salian Physiological 0.9% and for one month and used as negative control , the second group G2 was have induced diabetes before the month of dosage extract aqueous coriander seeds used as positive control , and the third group G3 has induced diabetes by injected with alloxan and administration orally month after extract aqueous coriander seeds and a dose of 50 mg / kg of body weight per day for a month , and the fourth group G4 was induced with by the injected with alloxan and administration orally after One month from the development of diabetes extract aqueous coriander seeds and a dose of 100 mg / kg of body weight per day for a month , and the fifth group G5 was induced diabetes by the injected with alloxan and administration orally month after the development of diabetes extract aqueous coriander seeds and a dose of 150 mg / kg of body weight per day for a month . Blood samples were collected from all groups before the induction of diabetes, a month after the induction of diabetes , and after a month of dosing extract aqueous coriander seeds in order to evalute the following criteria: Hemoglobin (Hb Red blood cells count (R.B.C), white blood cells count (W.B.C), Blood Glucose, Aspartate transaminase (AST), Alanine transaminase (ALT) and Alkaline phosphatase (ALP), the results of the present study showed : Results of the study showed that the development of diabetes in male rabbits led to a significant increase P<0.05 level in Hb, and R.B.C, and low non significant P>0.05 in the W.B.C compared to the positive control group . Also high moral P<0.05 level in the Hb and non significant increase P>0.05 in the number of R.B.C significant decrease (P<0.05) in the number of W.B.C aggregates in treatment extract aqueous coriander seeds , compared to the control positive group . The results of the study, revealed that the development of diabetes in male rabbits led to a significant increase P<0.05 in the concentration of glucose , and effectiveness of the enzymes and liver function AST, ALT, ALP and effectiveness of enzymes and liver function AST, ALT, ALP and lower non- significant P>0.05 at a dose 50 mg / kg of body weight in ALT a compared to the positive control group . In conclusion that the use of aqueous extract of coriander used in this study serves to reduce or prevent the occurrence of physiological and biochemical changes caused by diabetes.

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