Spontaneous Abortion and Failure of HumanCytotrophoblasts to adopt a vascular adhesion phenotype

Ahmed Shamran, Haider; Gani Hussain, Alaa; Al-Obaidi, Baqer; Asmaa,

	Spontaneous Abortion and Failure of HumanCytotrophoblasts to adopt a vascular adhesion phenotype
Journal of the Faculty of Medicine
Article 1, Volume 48, Issue 4, 2006, Pages 402-406
Authors
Haider Ahmed Shamran; Alaa Gani Hussain; Baqer Al-Obaidi;
Abstract
Background: Differentiating cytotrophoblasts transform their adhesion receptor phonotype so as to resemble the endothelial cells they replace a process that is required for normal placentation, and any defect in this adhesion phenotype switch might lead to pregnancy failure.Patients and Methods: Curate samples of the materno-fetal interface were taken from 20 women with spontaneous first trimester abortion and 6 control women undergone elective termination of pregnancy in the first trimester. Immunohistochemistry analysis of paraffin embedded sections of these curate samples was performed using monoclonal antibodies for cytokeratin, PECAM-1 and VCAM-1.Results: Cytokeratin showed positive immunostaing of the cytotrophoblasts lining the blood vessels, and PECAM-1 was positive in the cytotrophoblasts in only two cases who had elective termination of their pregnancy, while VCAM-1 immunostaining of thecytotrophoblasts was positive in three cases that had elective termination of pregnancy and only two cases that had spontaneous abortion.Conclusion: Defective expression of endothelial cell adhesion molecules in human cytotrophoblasts might predispose to abnormal placentation, pregnancy failure and subsequent abortion
Keywords
abortion; cytotrophoblasts; PECAM; VCAM

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