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Beta-Carotene, Glycemic Control And DyslipidemiaIn Type 2 Diabetes Mellitus | ||
| Journal of the Faculty of Medicine | ||
| Article 1, Volume 48, Issue 4, 2006, Pages 435-441 | ||
| Authors | ||
| Hashim M. Hashim; Ghassan A.Al-Shamma; Hayder Ali Mohammed | ||
| Abstract | ||
| Background : Diabetes mellitus is a stressful condition in which the increased production of free radicals impairs the generation of naturally occurring antioxidants like vitamins and carotenoids .Aim :The present study deals with the changes in serum ß-carotene in type 2 diabetes mellitus, as modulated by glycemic control and oxidative stress . Subjects & methods : Multiple biochemical parameters were obtained from plasma of 57 patients with type 2 diabetes mellitus ( 25 males and 32 females ) , on oral hypoglycemic with a disease duration of 1- 15 years and 37 healthy normal subject s of matching age and sex to serve as controls . The biochemical parameters measured in the present study included the glycated Hb (HbA1c ), serum lipids ( total cholesterol TC, triglycerides TG , high and low density lipoprotein cholesterols , HDL-C & LDL-C ) , lipid peroxides and serum ß-carotene.results revealed a marked reduction of ß- carotene in the diabetics in a pattern proportional to that of the glycemic control ,dyslipidemia and oxidative stress . Possible causes , mechanisms and suggestions underlining these changes are discussed. | ||
| Keywords | ||
| carotene; diabetes mellitus; Oxidative stress; Oxidized Lipoproteins | ||
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