A. Mutar, M., K. Kmal, R., F. Jawad, S. (2014). Synthesis and characterization of new biodegradable polyurethanes containing azo derivatives of 5-aminosalicylic acid. , 0(55), 275-300.
Mohammed A. Mutar; Rafid K. Kmal; Sabrean F. Jawad. "Synthesis and characterization of new biodegradable polyurethanes containing azo derivatives of 5-aminosalicylic acid". , 0, 55, 2014, 275-300.
A. Mutar, M., K. Kmal, R., F. Jawad, S. (2014). 'Synthesis and characterization of new biodegradable polyurethanes containing azo derivatives of 5-aminosalicylic acid', , 0(55), pp. 275-300.
A. Mutar, M., K. Kmal, R., F. Jawad, S. Synthesis and characterization of new biodegradable polyurethanes containing azo derivatives of 5-aminosalicylic acid. , 2014; 0(55): 275-300.

Synthesis and characterization of new biodegradable polyurethanes containing azo derivatives of 5-aminosalicylic acid

Iraqi National Journal Of Chemistry
Article 1, Volume 0, Issue 55, 2014, Pages 275-300
Authors
Mohammed A. Mutar; Rafid K. Kmal; Sabrean F. Jawad
Abstract
Abstract
The purpose of this study is to develop colon-specific drug delivery systems with pH-sensitive drug release properties.The azo polyurethane were characterized, and the drug content of the azo polyurethane was determined.Their behaviour and hydrolytic degradation was studied in simulated gastric fluid (SGF, pH =4) and simulated intestinal fluid (SIF, pH =7.8).
All synthesized monomers and polymers were characterized by FTIR, 1H-NMR spectra.The release of 5-ASA under physiological conditions (pH = 7.8 and
pH = 4) was investigated at body temperature (37 ºC). The release rate of 5-ASA increased with increasing pH (7.8 > 4).
Keywords
aminosalicylic acid; biodegradable polyurethanes; azo derivatives
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