The Application of ImmunohistoChemical  Markers for Diagnosis, Classification and Grading of Neuroendocrine Tumors

Musa Al.Turaihi, Kaswer; Al-Waidh, Roaahameed

	The Application of ImmunohistoChemical Markers for Diagnosis, Classification and Grading of Neuroendocrine Tumors
kufa Journal for Nursing sciences
Article 1, Volume 4, Issue 3, 2014, Pages 63-70
Authors
Kaswer Musa Al.Turaihi; Roaahameed Al-Waidh
Abstract
objectives: To study the sensitivity of Chromogranin A in the diagnosis of neuroendocrine tumors from various locations in the body and its association with clinicopathological parameters like site and grade of tumors . methodology: This study is conducted in the Department of Pathology, Faculty of Medicine, University of Kufa from January - October 2013. A total of 50 patients with neuroendocrine tumors from different locations. their ages ranging between 22-80 years with a mean age of 48.3 years. Two step Envision TM flex method was employed forimmunohistochemical detection of ki67 antigen (MIB -1) and Chromogranin A . Results: Main site for patients with neuroendocrine tumors included in this study is gastroenteropancreatic system and there is female predominance , from 50 patients 44 (88%) cases was positive for Chromoranin A expression , there was no significant differences in expression of the Chromogranin A with location and grade of tumors (P value >0.05) Conclusion: Chromogranin A is highly sensitive marker in diagnosis of neuroendocrine tumors irrespective to tumors location and tumor grade . Recommendation: We advise to use Chromogranin A immunohistochemical marker as a main marker in diagnosis of neuroendocrie tumors in addition to that this marker can be used as target for new modality in tumor therapy .
Keywords
neuroendocrine tumor; chromogranin A

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