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Spectrophotometric Determination of Dopamine in Pharmaceutical Formulations by Reaction with Tyramine | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 21, Issue 5, 2010, Pages 149-157 | ||
| Author | ||
| Mohammed .J.M. Hassan | ||
| Abstract | ||
| A batch Spectrophotometric method have been developed for the determination of dopamine in aqueous solution and in pharmaceutical ampoules preparation .The methods are based on the reaction of dopamine with tyramine in presence of potassium metaperiodate as oxidizing agent .The water soluble orange color produced was measured at 472 nm .the range linearity was observed from 0. 5 – 20 µg.ml-1 dopamine with quantification limits of 0.28 µg.ml-1 dopamine. The effects of chemical and physical parameters have been carefully considered and the proposed methods were successfully applied to the determination of dopamine in ampoules formulation. | ||
| Keywords | ||
| catecholamine; Dopamine; tyramine; Pharmaceutical Formulations | ||
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