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The level of IL-1α, IL-10 and IL-17A in Alzheimer's disease patients: Comparative study | ||
| Baghdad Science Journal | ||
| Article 1, Volume 11, Issue 4, 2014, Pages 1486-1492 | ||
| Authors | ||
| Amir F. Alhaidary; Ali H. Adhia; Alice K. Melconian; Alaa A. Hamdan | ||
| Abstract | ||
| The objective of this study is to evaluate the level of cytokines IL-1α, IL-10 and IL-17A in the serum of patients with Alzheimer's disease (AD), vascular dementia (VD) and down syndrome (DS). The results showed that Serum level of IL-1α was significantly increased in AD patients (3.79 ± 0.26 pg/ml) as compared with DS patients (2.78 ± 0.39 pg/ml) or controls (2.78 ± 0.22 pg/ml), while no significant difference was observed between AD and VD (3.25 ± 0.20 pg/ml) patients or between VD patients, DS patients and controls. The serum level of IL-10 was approximated in VD and DS patients and controls (3.39 ± 0.24, 2.77 ± 0.39 and 3.41 ± 0.35 pg/ml, respectively), but was significantly (P ≤ 0.05) increased in AD patients (5.73 ± 0.55 pg/ml) as compared to these groups. The serum level IL-17A was significantly increased in AD and VD patients (6.28 ± 0.35 and 5.32 ± 0.42 pg/ml, respectively) as compared with DS patients (3.75 ± 0.40 pg/ml) or controls (4.05 ± 0.28 pg/ml).IL-10 is important to diffrentiation between AD and VD. | ||
| Keywords | ||
| Alzhiemer; A cytokines | ||
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