Salman, H., Hussein Zmam, E. (2012). Synthesis and Characterization Some Novel Barbituric Acid Derivatives from Sulfadiazine. , 0(6), 86-100.
Hawraa Salman; Ezat Hussein Zmam. "Synthesis and Characterization Some Novel Barbituric Acid Derivatives from Sulfadiazine". , 0, 6, 2012, 86-100.
Salman, H., Hussein Zmam, E. (2012). 'Synthesis and Characterization Some Novel Barbituric Acid Derivatives from Sulfadiazine', , 0(6), pp. 86-100.
Salman, H., Hussein Zmam, E. Synthesis and Characterization Some Novel Barbituric Acid Derivatives from Sulfadiazine. , 2012; 0(6): 86-100.

Synthesis and Characterization Some Novel Barbituric Acid Derivatives from Sulfadiazine

Journals kufa for chamical
Article 1, Volume 0, Issue 6, 2015, Pages 86-100
Authors
Hawraa Salman; Ezat Hussein Zmam
Abstract
Schiff bases [A1-A3] were synthesized by condensation of sulfadiazine with aromatic aldehyeds such as [(4-dimethylamino)benzaldehyde,4-methoxybenzaldehyed and 4-bromo benzaldehye] in hot glacial acetic acid, then addition reaction of Schiff bases with acetyl chloride in benzene afforded new tertiary amides compounds [B1-B3] which undergo to the nucleophilic substitution reaction with [urea, thiourea and guanidine carbonate] in basic medium to give diamino compounds derivatives [C1a,b,c-C3a,b,c]. Diethyl malonate undergoes condensation reaction in basic medium with last compounds so as to get novel barbituric acid derivatives [D1a,b,c-D3a,b,c]. These acid derivatives were identified by elemental analysis [C.H.N.S] analysis, [F.T.I.R] and [1H-NMR] spectrum.
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