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Histological and ultrastructural studies on the liver of mice after treatment with single dose of LD50 Naja naja snake venom | ||
| Magazine of Al-Kufa University for Biology | ||
| Article 1, Volume 6, Issue 2, 2014, Pages 131-143 | ||
| Authors | ||
| Taha Shawi Morad; Maysoon .A. Ahmad; Najat Mutar | ||
| Abstract | ||
| Histopathological and ultrastructural changes in liver tissues following intraperitoneal (i.p.) single LD50 of Naja naja snake venom (0. 055μg/g) body weight were studied. Tissues were obtained for histological and ultrastructural studies at 3 h and 24 h time intervals following injection of venom. Material and methods: A total of 18 adult male albino mice were used; divided into three groups; each containing 6 rats: First group: as control.Second and third group: treaded with i.p. single LD50 of Naja naja snake venom (0. 055μg/g) body weight , sacrificed after 3 and 24h respectively.The liver of the control and treated mice were dissected out for histological and ultrastructural examinations . Results: Histopathological and ultra structural degenerative effects in the form of vacuolar degeneration, hydropic degeneration , lymphocytic infiltration , Kupffer cells hyperplasia , mitochondria were condensed darkly stained in most of the hepatic cells, lipid droplets were noticed in venom treated mice liver. Karyolysis and karyorrhexis were also seen. . Conclusion: snake-envenoming causes several disorders such as intrahepatic hemorrhage , liver necrosis and hepatotoxicity. | ||
| Keywords | ||
| liver tissues; snake venom; intraperitoneal | ||
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